Tetrahydropalmatine (THP) Q&A Guide | Natural Non-addictive Pain Relief & Sedative Raw Material for Overseas B2B Buyers

1. Basic Knowledge Q&A

1. What is Tetrahydropalmatine (THP)?

Tetrahydropalmatine, abbreviated as THP, also known as Corydalis B, is a natural plant alkaloid extracted and purified from traditional Chinese herb Corydalis Rhizoma via low-temperature extraction method. It is mainly divided into DL-THP (racemate) and high-activity L-THP (levorotatory form). L-THP delivers stronger efficacy and is the mainstream raw material widely used in pharmaceutical industry.

2. What category does THP belong to?

It is classified as a non-opioid central sedative and analgesic raw material, belonging to nervous system functional ingredients. It is neither hormone, antibiotic nor stimulant ingredient, featuring wide application range and low market access threshold.

3. Is THP a drug? Is it allowed for export and customs clearance?

Genuine pharmaceutical-grade and food-grade Tetrahydropalmatine is NOT a drug of abuse. It is not categorized as narcotic drugs or psychotropic controlled substances with no trade restrictions. It holds complete legal import & export qualifications and can pass customs smoothly in most countries worldwide.

Note: THP cigarettes and euphoric atomized products circulating in the market are counterfeit goods illegally mixed with prohibited ingredients, which have nothing to do with high-purity refined THP raw materials supplied by formal factories. Buyers are advised to choose qualified factory-sourced raw materials only.

4. What is thp keti? Is it related to Tetrahydropalmatine?

Thp keti is an informal folk term without official pharmaceutical definition, generally referring to illegally compounded raw materials. It has no connection with pure Tetrahydropalmatine, so formal foreign trade procurement shall avoid such unknown substances.

2. Pharmacological Effects Q&A

1. What are the main pharmacological effects of L-THP?

– Mild and effective pain relief: works well on visceral pain, chronic pain, headache, dysmenorrhea and mild to moderate postoperative pain.
– Sedation and sleep improvement: relieves nervous tension and effectively improves insomnia caused by physical pain.
– Auxiliary benefits: helps stabilize blood pressure, regulate heart rhythm and relieve gastrointestinal discomfort; it also assists in easing physical discomfort during substance withdrawal period.

2. What is the mechanism of action of Tetrahydropalmatine?

It does not act on opioid receptors. It exerts effects by regulating central nervous neurotransmitters, blocking dopamine D2 receptors and inhibiting pain signal transmission. Its core advantage is eliminating physical dependence and addiction risks fundamentally, making it much safer than traditional analgesic ingredients.

3. What is the half-life of Tetrahydropalmatine? Is it metabolized safely?

The oral elimination half-life is about 9.8 hours with stable and long-lasting efficacy. After entering human body, it is metabolized gently. Most active ingredients can be excreted through urine within 12 hours without substance accumulation in the body, ensuring high safety for long-term application.

3. Ingredients & Specifications Q&A

1. Does high-purity THP contain other pharmaceutical ingredients?

Export-grade pure Tetrahydropalmatine consists of single active ingredient only. It contains no morphine, opioids, cannabinoids or any prohibited psychoactive substances. With pure and stable composition, it meets the testing standards of food and pharmaceutical raw materials in Europe, America, Southeast Asia and other regions.

2. What are the regular specifications of bulk Tetrahydropalmatine?

– Purity: ≥98%, tested strictly by HPLC
– Appearance: white to off-white crystalline powder
– Standard package: 25kg sealed drum, customized small packages are acceptable

3. Are there special requirements for storage and transportation?

Store in sealed condition at room temperature, keep away from light and moisture. No cold chain transportation is required, which is convenient for sea freight and land freight globally.

4. Side Effects & Safety Q&A

1. What side effects does Tetrahydropalmatine have?

Under standard dosage, side effects are extremely mild and rare. Common reactions include temporary drowsiness, slight dizziness, dry mouth and fatigue, which will relieve spontaneously within 1 to 2 hours without causing organic physical damage.

2. Who are not suitable to use THP raw materials and tablets?

Pregnant women, breastfeeding women, patients with extrapyramidal diseases and people allergic to plant alkaloids are not recommended to use it. It is highly safe for ordinary adults when used in compliance with regulations.

3. Will long-term use cause dependence?

It will not lead to psychological addiction or physical dependence. Only slight tolerance may occur after long-term use, and there are no withdrawal symptoms after discontinuation, so it is suitable for mass production of health supplements and oral preparations in the long run.

5. Application Fields Q&A

1. What products can Tetrahydropalmatine be applied to?

– Pharmaceutical industry: analgesic tablets, sedative sleeping aids, menstrual conditioning products, postoperative soothing preparations
– Dietary supplement industry: natural sleep-improving capsules, herbal pain-relief tablets, mood-soothing health products
– Scientific research field: used as pharmaceutical intermediates for research and development of new drugs targeting nervous system and cardiovascular diseases

2. What are THP cigarettes? Are they allowed for trading?

Informal THP cigarettes are modified illegal products usually mixed with prohibited ingredients, which are forbidden to purchase and circulate. Foreign traders are only permitted to trade pure raw material powder instead of herbal cigarettes or atomized finished products.

6. Overseas Procurement Cooperation Q&A

1. What are your advantages in exporting Tetrahydropalmatine?

– Sufficient and stable supply with independent production lines supporting mass production
– COA certificates and test reports are available for each batch, third-party re-inspection is supported
– Complete set of official export documents including customs declaration documents and certificates of origin to ensure smooth global customs clearance

2. Can you provide customized services?

We supply both L-THP and DL-THP as required. Customized purity standards and package specifications are available according to clients’ formula demands. We also provide technical support including product application solutions, English documents and formula references.

3. How can overseas buyers get samples and place orders?

Overseas purchasers can apply for free samples first for quality inspection. We will discuss bulk order details and long-term cooperative prices after quality confirmation. We guarantee fast delivery and considerate one-to-one after-sales service.

Industry Summary

Against the backdrop that the global health industry strictly restricts prohibited ingredients and vigorously promotes natural plant raw materials, Tetrahydropalmatine with non-addictive property, high safety and wide usability is witnessing growing market demand, becoming a stable long-term hot-selling product in foreign trade raw material business.

Shaanxi Astro Biology Co., Ltd. has been focusing on the export of plant extracts and pharmaceutical functional raw materials for years. Our high-purity Tetrahydropalmatine features stable quality and competitive price, winning trusted cooperation clients across Europe, Southeast Asia, America and other regions.

Feel free to contact us for sample application, quotation inquiry and raw material purchasing plans. We are committed to providing reliable one-stop raw material supply services for global partners.

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