O-Phospho-L-serine CAS 407-41-0

1. Product Introduction

Many research institutions and pharmaceutical laboratories frequently encounter a common problem when purchasing biochemical raw materials: variable biological activity between batches leads to unrepeatable experimental data. This delays research progress and wastes lab resources and research funding.

O-Phospho-L-serine (CAS 407-41-0) is a vital phosphorylated amino acid derivative and the direct precursor in the L-serine biosynthesis pathway. It features unique and stable dual regulatory effects on metabotropic glutamate receptors, making it an essential standard biochemical reagent for global neuroscience research focusing on mGluR function.

We adopt standardized purification processes with strict impurity control to guarantee consistent physical properties and biological activity across all batches. Our product meets the requirements for short-term verification tests, long-term continuous research projects, and pre-clinical target discovery for neuro-related innovative drugs. We support worldwide export.

2. Product Specifications

– Product Name: O-Phospho-L-serine
– Synonyms: 3-phospho-L-serine, P-serine, L-SOP
– CAS No.: 407-41-0
– Molecular Formula: C₃H₈NO₆P
– Molecular Weight: 185.07
– Appearance: White crystalline powder
– Grade: Research / Biochemical Grade
– Storage Condition: Sealed, store in a cool, dry and dark place
– Key Features: Stable biological activity, excellent batch consistency, reliable physicochemical stability

3. Core Biological Activity

The primary value of O-Phospho-L-serine lies in its selective regulation of metabotropic glutamate receptors (mGluRs), with clear targets and steady performance without obvious batch-to-batch deviation:

3.1 Agonist Activity

Selectively activate Group III mGluRs: mGluR4, mGluR6, mGluR7, mGluR8

3.2 Antagonist Activity

Exert inhibitory effects on mGluR1 and mGluR2

Thanks to this distinctive biological characteristic, it serves as a core tool compound for studying glutamate signal transduction and synaptic regulation mechanisms, and is widely applied in various in-vitro cell experiments and receptor function screening models.

4. Application Fields

4.1 Fundamental Neuroscience Research

It is used for analysis of glutamate receptor signaling pathways, exploration of neural cell transduction mechanisms, and research related to the central nervous system and retina. It is routinely sourced by universities and neuroscience laboratories globally.

4.2 Amino Acid Metabolism Research

As a key precursor for L-serine synthesis, it is applied in research on amino acid metabolic pathways, cellular biochemical synthesis mechanisms and cell homeostasis.

4.3 Neurological Drug Discovery

Suitable for target validation of drug candidates for neurological disorders, pharmacological activity screening, and pre-clinical basic pharmacodynamic evaluation in early-stage new drug development.

4.4 Academic Research & Control Experiments

Perfect for thesis-supported experiments, long-term research projects and parallel control tests. Consistent quality effectively reduces variable interference in experiments.

5. Quality & Supply Advantages

✅ Stable receptor activity. Standardized production minimizes batch differences to ensure repeatable experimental results
✅ White high-purity crystalline powder. Strict control of heavy metals and related impurities for high-precision in-vitro research
✅ Good physicochemical stability. Resists moisture absorption and degradation. Well-adapted to long-term storage and transoceanic shipping
✅ Flexible order options: lab-scale samples, small bulk orders and large long-term supply available
✅ COA supplied for every batch, complete chromatographic and activity data for full traceability
✅ Full set of export documents including MSDS, meeting import inspection and customs clearance requirements for laboratories worldwide

6. Frequently Asked Questions

Q1: What kinds of experiments is this product suitable for?

A: It is mainly used for in-vitro agonist/antagonist tests of metabotropic glutamate receptors, neuroscience mechanism research, L-serine cellular metabolism studies, and target screening for neuro-related new drugs.

Q2: Is the activity consistent among different batches?

A: The whole purification process is standardized with fixed raw materials and production parameters. High batch consistency avoids fluctuations that may affect long-term experimental results.

Q3: Can I get samples for preliminary testing?

A: Yes, lab samples are available for preliminary trials to verify compatibility with your experimental protocols.

Q4: Will activity change during transportation?

A: The product is packed in moisture-proof and light-proof aluminum foil bags. It maintains good stability under normal sea and air transport conditions. Activity will not decline significantly if stored properly upon arrival.

7. Inquiry & Cooperation

If you are seeking research-grade O-Phospho-L-serine CAS 407-41-0 with stable biological activity, please contact us to obtain samples, complete technical documents and the latest quotation.

Shaanxi Astro Biology Co.,Ltd