Vitamin E Polyethylene Glycol Succinate (TPGS) CAS 9002-96-4 | USP Grade Solubilizer for Targeted Pharmaceutical Formulations

Core Purchasing Advantage

Vitamin E Polyethylene Glycol Succinate (TPGS), also known as Tocofersolan or D-α-Tocopheryl Polyethylene Glycol Succinate, is a pharmacopoeia-grade amphiphilic pharmaceutical excipient, CAS No. 9002-96-4, specially developed for solubilizing poorly soluble APIs and supporting research on targeted drug delivery systems.

Different from general daily chemical-grade surfactants, our Vitamin E Polyethylene Glycol Succinate (TPGS) is strictly manufactured in line with USP specifications, with a full set of audit documents available for overseas pharmaceutical factory qualification inspections. It is an indispensable key raw material for solid dispersions, liposomes and anti-tumor targeted prescriptions. Once the formulation is finalized with our material, the switching cost is extremely high, bringing long-term repeat orders and high customer loyalty, making it a high-growth premium product in the pharmaceutical excipient industry.

Basic Product Specifications

– Common Name: Vitamin E Polyethylene Glycol Succinate (TPGS)
– Alternative Name: Tocofersolan
– Full Chemical Name: D-α-Tocopheryl Polyethylene Glycol Succinate
– CAS Number: 9002-96-4
– Appearance: White to pale yellow waxy solid
– Structural Feature: Amphiphilic molecular structure containing lipophilic vitamin E segment and hydrophilic PEG long chain, delivering outstanding surfactant properties

5 Irreplaceable Technical Strengths for Pharmaceutical Formulation

1. Superior Water Solubility to Break Limitations of Lipophilic Ingredients
Conventional vitamin E is only soluble in oils, while Vitamin E Polyethylene Glycol Succinate (TPGS) can disperse uniformly in aqueous solutions. It acts as a dedicated solubilizer for hydrophobic active pharmaceutical ingredients, greatly expanding formulation options for oral and mucosal delivery systems.
2. Powerful Permeation Enhancement to Boost Drug Bioavailability
It effectively improves the permeability of gastrointestinal and mucosal epithelia, significantly elevating the oral absorption rate of poorly absorbed drugs, and is widely adopted for generic drug consistency evaluation and prescription upgrading projects.
3. Multi-functional Integrated Excipient to Lower R&D & Registration Costs
It combines solubilizing, emulsifying, dispersing and plasticizing capabilities in a single material. One Vitamin E Polyethylene Glycol Succinate (TPGS) can replace multiple separate excipients, shortening formulation development cycles and simplifying regulatory registration procedures.
4. Unique P-gp Inhibitory Activity for Targeted Oncology Medicines
It is capable of reversing multidrug resistance in tumor cells, holding irreplaceable application value in targeted delivery and sustained-release innovative pharmaceuticals, with higher profit potential compared with bulk generic excipients.
5. Broad Formulation Compatibility for Cutting-edge Drug Delivery Technologies
With stable physicochemical properties, Vitamin E Polyethylene Glycol Succinate (TPGS) is applicable to liposomes, micelles, solid dispersions, ophthalmic drops, nasal sprays and other advanced dosage forms, perfectly matching the global R&D trend of innovative medicines.

Priority Application Fields

1. Oral Solid Dispersions

Vitamin E Polyethylene Glycol Succinate (TPGS) serves as the core solubilizing carrier for hydrophobic anti-tumor drugs and chronic disease APIs to accelerate dissolution rate. It has been fixed in the approved prescriptions of numerous European and American generic drugs, maintaining stable bulk orders all year round.

2. Targeted & Sustained-Release Innovative Preparations

Vitamin E Polyethylene Glycol Succinate (TPGS) can be constructed into micelle and liposome targeted delivery systems to precisely control drug release sites and release speed. It is mainly applied in anti-cancer new drugs and long-acting sustained-release formulations, where clients hold high tolerance for premium quality standards.

3. Ophthalmic & Nasal Mucosal Delivery Preparations

Mild and non-irritating, Vitamin E Polyethylene Glycol Succinate (TPGS) integrates solubilization and permeation promotion functions, acting as a fully compliant excipient for eye drops and nasal sprays. Its global demand from ophthalmic pharmaceutical manufacturers keeps rising steadily.

4. Premium Dietary Supplements & Functional Beverages

Vitamin E Polyethylene Glycol Succinate (TPGS) is applied to manufacture water-soluble vitamin E oral liquids and sports nutrition drinks, solving the long-standing bottleneck that traditional vitamin E cannot be formulated in water-based systems.

Why Global Pharmaceutical Enterprises Choose Us as Long-term Fixed Suppliers

1. High-end Niche Track with Ample Profit Margins
High qualification thresholds for pharmaceutical-grade certification effectively avoid vicious price competition among bulk raw materials, leaving sufficient profit space for both formulation factories and professional distributors.
2. High Prescription Dependency with Very High Supplier Switching Cost
Replacing an approved Vitamin E Polyethylene Glycol Succinate (TPGS) supplier for marketed prescriptions requires repeated stability testing and supplementary registration filings. Qualified suppliers can obtain long-term stable cooperation once admitted into the formal supply chain.
3. Full Pharmacopoeia Compliance, Fully Audit-ready
Our material complies with USP and EP standards. Complete COA, process validation documents and impurity research packages are available to support on-site supplier audits, meeting pharmaceutical access requirements across Europe, America, Southeast Asia and the Middle East.
4. Expanding Upward Market Demand in the Biopharma Industry
Booming global R&D on targeted and sustained-release drugs continuously expands the application boundaries of Vitamin E Polyethylene Glycol Succinate (TPGS), ensuring steady long-term market growth potential.

Customized Export Supply Solutions for Pharmaceutical Clients

We specialize in supplying audit-grade Vitamin E Polyethylene Glycol Succinate (TPGS) to global pharmaceutical factories and R&D laboratories:

✅ In-stock pharmaceutical-grade stock with uniform waxy texture and highly consistent molecular weight distribution, equivalent to top international brand standards
✅ Batch-wise full COA provided, customized complete audit document packages available on request
✅ Free R&D sample support, small trial orders and personalized export packaging are acceptable
✅ Strict control over heavy metals, related substances and other impurities to meet stringent formulation requirements
✅ Long-term fixed-price supply contracts are negotiable, with one-stop global ocean export delivery service

Target Buyer Groups

Pharmaceutical excipient importers, generic drug manufacturers, biotech enterprises, pharmaceutical R&D laboratories, ophthalmic drug producers, high-end dietary supplement brands and professional fine chemical distributors.