Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca) USP Grade | CAS 151533-22-1 | Active Folate Powder

Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca) is the calcium salt of 6S-L-5-methyltetrahydrofolate, the biologically active form of folate (vitamin B9). With CAS 151533-22-1 and manufactured to USP monograph standards, this premium-grade ingredient offers superior stability, high purity, and optimal bioavailability compared to regular folic acid. Also known as calcium levomefolate or L-methylfolate calcium, it bypasses the MTHFR enzyme, ensuring direct utilization by the body—ideal for formulations targeting methylation support, prenatal health, and cardiovascular wellness.

Core Advantages

1. USP Compliance: Manufactured under current Good Manufacturing Practices (cGMP) and meets the latest USP standards for identity, purity, and potency.
2. Superior Bioavailability: L-5-MTHF-Ca is the metabolically active form of folate, with ~1.7× higher bioavailability than folic acid. It does not require conversion by the MTHFR enzyme, making it suitable for individuals with MTHFR polymorphisms.
3. High Purity & Stability: Strict control of impurities (total related substances ≤2.5%) and low D-isomer content ensure consistent quality. The calcium salt form provides excellent stability, with a shelf life of 24–36 months under proper storage.
4. Certified Quality: Non-GMO, Halal, and Kosher certified; suitable for global markets and diverse dietary requirements.

Practical Application Cases of L-5-MTHF-Ca

Different from synthetic folic acid, L-5-Methyltetrahydrofolate Calcium is the only natural active folate that can be directly absorbed and utilised by the human body. Relying on strict USP grade production standards, our L-5-MTHF-Ca raw material has been widely adopted by health product manufacturers, pharmaceutical factories and functional food brands worldwide, with mature and mass-produced application cases in multiple fields.

1. Prenatal & Postnatal Nutritional Supplements

This is one of the most mainstream application scenarios for L-5-MTHF-Ca.
Many professional prenatal nutrition brands replace traditional folic acid with USP grade L-5-MTHF-Ca in comprehensive prenatal multivitamin formulas. It effectively helps pregnant women and preparing mothers maintain normal folate levels, reduce the risk of fetal neural tube abnormalities, and solve the problem of poor folate metabolism caused by MTHFR gene mutation.
It is also widely added in postpartum recovery nutrition powder and women’s daily care compound nutrition tablets, mild and non-irritating, suitable for long-term daily supplementation.

2. Cardiovascular & Homocysteine Management Formulas

High homocysteine is a key risk factor for cardiovascular sub-health problems.
As a core ingredient for methylation circulation, L-5-MTHF-Ca is compounded with vitamin B12, vitamin B6 and betaine in many middle-aged and elderly health products. It assists the body in normal homocysteine metabolism, supports blood vessel health and cardiovascular maintenance, and is a classic compound formula favoured by European and American health food markets.

3. Methylation Support & Chronic Metabolic Care Products

More consumers pay attention to body methylation balance now.
Our USP L-5-MTHF-Ca raw materials are used in professional methylation support complex supplements, matching with N-Acetylcysteine, magnesium and plant active extracts. It helps improve physical metabolism, relieve sub-health fatigue, assist liver detoxification and cell repair, and is popular in high-end boutique nutrition brands and functional customization lines.

4. Prescription & OTC Pharmaceutical Preparations

Qualified USP-grade raw materials meet pharmaceutical-level access standards.
L-5-MTHF-Ca is used in pharmaceutical folate deficiency treatment tablets and compound nutritional injections, applied in clinical auxiliary improvement of megaloblastic anemia, malabsorption syndrome and long-term irregular diet-induced folate deficiency. Strict impurity control and stable batch-to-batch quality fully comply with pharmaceutical raw material filing requirements.

5. Functional Fortified Food & Special Diet Food

In the global functional food market, active folate fortification has become a development trend.
L-5-MTHF-Ca can be stably added in meal replacement powder, nutritional cereal bars, special medical formula food and elderly fortified milk powder. It maintains high activity in conventional processing technology, makes up for the loss of natural folate in food processing, and meets the folate supplement needs of special groups such as the elderly, vegetarians and people with weak absorption.

6. Sports Nutrition & Energy Support Formulas

For fitness crowds and people with high physical consumption, reasonable folate intake helps cell energy metabolism and red blood cell synthesis.
Many sports nutrition brands add micro-dose L-5-MTHF-Ca to comprehensive energy supplements and compound mineral tablets, to support long-term exercise recovery and maintain body normal physiological functions, with high safety and good compound compatibility.

Why Choose Our L-5-MTHF-Ca?

We specialize in supplying USP-grade Calcium L-5-Methyltetrahydrofolate (CAS 151533-22-1) with full traceability and third-party testing. Our commitment to quality ensures every batch meets strict USP specifications, delivering consistent performance for your formulations. Whether you need bulk powder, custom packaging, or OEM support, we offer flexible solutions to match your production scale.

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Request a free quote or COA (Certificate of Analysis) today. Our team provides fast response, reliable delivery, and dedicated technical support for all your active folate ingredient needs.