Calcium D Glucarate – High Purity Powder for Liver Detox & Hormone Balance
Core Physical & Chemical Parameters
– CAS No.: 5793-89-5
– Molecular Formula: C₆H₈CaO₈·4H₂O
– Molecular Weight: 320.26
– Appearance: White to off-white crystalline powder, no visible impurities, no agglomeration
– Purity: ≥98.5% (HPLC detection, in line with USP, EP, BP latest pharmacopoeia standards)
– Loss on Drying: 18.0%-22.0% (conforming to tetrahydrate crystal water content requirements)
– pH Value: 6.0-8.0 (1% aqueous solution, neutral and mild, suitable for various formulation systems)
– Solubility: Slightly soluble in purified water, insoluble in organic solvents such as ethanol, acetone, and ether
– Heavy Metals: ≤10ppm, including lead, arsenic, mercury, cadmium and other harmful elements fully meet international export limits
– Microbial Limit: Total aerobic plate count ≤1000cfu/g, yeast and mold ≤100cfu/g, no Escherichia coli, Salmonella and other pathogenic bacteria
– Stability: Stable under normal temperature and pressure, non-hygroscopic, not easy to deteriorate under sealed conditions, resistant to conventional processing temperatures
Calcium D Glucarate (CAS 5793-89-5), also known as D-saccharic acid calcium salt tetrahydrate, is the tetrahydrate calcium salt form of D-saccharic acid, a natural acidic compound widely found in daily fruits and vegetables such as apples, grapes, broccoli, and Brussels sprouts. It appears as white or off-white crystalline Calcium D Glucarate powder, odorless, with a uniform particle size and good fluidity, making it easy to process and mix in downstream formulation production.
As a naturally derived, highly biocompatible raw material, Calcium D Glucarate is a well-recognized β-glucuronidase inhibitor in the global nutritional supplement, pharmaceutical, and food industries. Its core biological activity lies in regulating the body’s detoxification metabolism and hormone balance, with stable chemical properties, low irritation, and high safety, fully complying with international food and pharmaceutical raw material standards, and widely recognized by global downstream manufacturers.
Production Process & Quality Control
We adopt a natural plant extraction + green synthesis process to produce high purity Calcium D Glucarate, abandoning traditional chemical synthesis methods with high pollution and high residue, ensuring the product’s natural purity and environmental protection.
The whole production process strictly follows GMP quality management standards, covering raw material screening, enzymatic conversion, calcium salt complexation, recrystallization purification, low-temperature drying, precision crushing, and finished product packaging. Each production link is equipped with real-time monitoring and quality inspection points:
- Raw material screening: Select non-transgenic, pesticide-free plant raw materials, and conduct pre-testing on heavy metals and microorganisms;
- Purification process: Use multi-step recrystallization technology to remove residual impurities and organic solvents, ensuring Calcium D Glucarate purity exceeds 98.5%;
- Finished product testing: Each batch of products must pass HPLC purity detection, crystal water content analysis, heavy metal detection, and microbial detection, and issue a complete COA (Certificate of Analysis) and MSDS (Material Safety Data Sheet);
- Traceability management: Establish a complete production batch record system, realizing full traceability from raw materials to finished products, meeting the audit requirements of global customers.
In-depth Mechanism of Action
Inhibit β-glucuronidase, Boost Liver Detoxification
The liver is the core detoxification organ of the human body, and the phase II detoxification (glucuronidation reaction) is the key way for the body to expel toxins. β-glucuronidase is a enzyme that can decompose glucuronide conjugates, leading to the reabsorption of toxins, hormones and other metabolites into the blood, increasing the body’s metabolic burden.
Calcium D Glucarate can effectively inhibit the activity of β-glucuronidase in the intestine and liver, block the decomposition of glucuronide conjugates, promote the combination of environmental toxins, drug metabolites, excess bilirubin and glucuronic acid, and accelerate their discharge from the body through feces and urine, thereby reducing the accumulation of toxins in the body and protecting liver cell function.
Regulate Hormone Metabolism, Maintain Endocrine Balance
For excess steroid hormones (such as estrogen) in the body, most of them are metabolized by the liver and enter the intestine through bile. Under the action of β-glucuronidase, these hormones will be reabsorbed into the blood, causing hormone imbalance.
By inhibiting the activity of β-glucuronidase, Calcium D Glucarate blocks the enterohepatic circulation of excess hormones, promotes the stable excretion of redundant hormones, and maintains the balance of endocrine levels. It has a synergistic effect with ingredients such as DIM and I3C, and is widely used in the development of hormone balance health products.
Wide Application Fields
Dietary Supplement Industry
It is the core raw material for liver detoxification, hormone balance, and metabolic conditioning supplements. It can be made into capsules, tablets, powder packets and other dosage forms. It is suitable for people with high work pressure, long-term exposure to environmental pollutants, and irregular work and rest. It can be used alone or compounded with milk thistle extract, curcumin, chlorella and other ingredients to enhance the comprehensive effect of products.
Pharmaceutical Industry
Pharmaceutical grade Calcium D Glucarate is used as a pharmaceutical excipient, chelating agent and stabilizer, it can improve the stability and bioavailability of drug preparations; at the same time, it is used in the research and development of liver protection and detoxification drugs, with mild effect and good human tolerance, and no obvious side effects after long-term use.
Food Industry
Food grade Calcium D Glucarate is approved as a food nutrition fortifier and preservative auxiliary, it can be added to functional beverages, health food, solid drinks and other products. It can enhance the nutritional value of food, extend the shelf life of products, and is safe and non-toxic, in line with national and international food additive standards.
Cosmetic Raw Materials (Auxiliary)
Added to skin care products with anti-pollution and skin metabolism conditioning effects, it can help skin cells expel metabolic waste, improve dull skin condition, and has high biocompatibility, suitable for sensitive skin formula development.
Product Advantages & Supply Capacity
Quality Advantages
– High purity and low impurity: The HPLC detection purity of our Calcium D Glucarate is ≥98.5%, no organic solvent residue, no heavy metal exceeding standard, and meets the strict quality requirements of European and American markets;
– Natural and safe: Non-transgenic, no allergens, no artificial additives, compliant with FDA, EU food raw material regulations;
– Stable performance: Uniform particle size, good fluidity, easy to compress and mix, suitable for large-scale industrial production.
Supply & Service Advantages
– Stable supply: Large-scale industrial production, with sufficient inventory of conventional specifications, to ensure timely delivery of customer orders;
– Customized service: Support customized processing of particle size, purity, and packaging, to meet the personalized R&D and production needs of different customers;
– Professional support: Provide professional technical guidance, formula matching suggestions, and complete customs declaration documents to assist customers in smoothly completing import and export procedures;
– Perfect after-sales: Establish a professional after-sales team, respond to customer feedback within 24 hours, and solve product application problems in a timely manner.
Why Choose Our Calcium D Glucarate?
We have been focusing on the R&D, production and sales of natural plant extracts and pharmaceutical chemical raw materials for many years, with rich industry experience and advanced production technology. Our Calcium D Glucarate (CAS 5793-89-5) products are sold to more than 50 countries and regions i
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