Andrographolide Raw Material | Strong Anti-inflammatory & Antiedematous Effect

Andrographolide, also known as HMPL-004, is a natural diterpene lactone active monomer refined from Andrographis paniculata of the Acanthaceae family. It is extracted through low-temperature extraction and advanced purification processes and serves as the core active ingredient responsible for the medicinal value of Andrographis paniculata. Featuring stable properties, high purity, low impurity content and long-lasting activity, this product is widely applied in dietary supplements, pharmaceutical preparations, biological research and health care raw materials. It has become a highly recognized natural broad-spectrum plant active ingredient across global markets.

Detailed Efficacy & Functional Mechanism

1. Broad-Spectrum Antimicrobial & Antiviral Effects

Numerous pharmacological animal experiments have proven that andrographolide delivers potent inhibitory effects against pathogenic bacteria. It effectively restrains the reproduction of Diplococcus pneumoniae and beta-hemolytic streptococcus, relieving and reducing fever caused by bacterial infection, with stronger efficacy than neo-andrographolide.

In vitro tests also confirm its outstanding antiviral activity. It can inhibit the replication of HIV-related viruses, making it widely used in formula development for respiratory tract infections and viral inflammation.

2. Long-Lasting Antipyretic Effect for Infectious Fever

Andrographolide provides mild and stable relief for fever induced by endotoxin, pneumococcal infection and streptococcal inflammation.

Four major derivatives including andrographin A, B, C and D show antipyretic effects on fever caused by typhoid-paratyphoid vaccine and chemical irritants. Its fever-reducing effect is gentle and sustainable without sudden body temperature drop, perfectly suitable for heat-clearing health formula.

3. Powerful Anti-Inflammatory & Anti-Exudative Properties

All andrographolide monomers exert remarkable anti-inflammatory activities. At a routine dosage of 1g/kg, it significantly reduces increased capillary permeability triggered by xylene and acetic acid, relieving inflammation exudation, redness and swelling.

It alleviates acute exudation induced by croton oil and egg-white-induced paw edema in rats. Its anti-inflammatory effect is closely related to adrenal function and will disappear after adrenal resection. The anti-inflammatory potency ranking: Andrographin D > Andrographin C > Andrographin A > Andrographin B, enabling flexible formula customization.

4. Dual Immune Regulation & Body Defense Enhancement

Andrographolide regulates the whole process of cellular immunity. Its water decoction significantly improves the phagocytic ability of human white blood cells against pathogenic bacteria and enhances delayed-type hypersensitivity.

Related preparations can increase serum lysozyme levels and strengthen the phagocytic capacity of peritoneal macrophages and neutrophils. Long-term administration of andrographolide sulfonate notably boosts the clearance of pneumococcus and Staphylococcus aureus by peripheral immune cells. Its derivatives balance excessive immune response and maintain long-term immune system stability.

5. Anti-Implantation & Anti-Pregnancy Pharmacological Effects

Natural andrographolide presents obvious anti-implantation and pregnancy-termination activity. Multiple administration methods including oral, intraperitoneal, intravenous, intrauterine and subcutaneous injection are all effective. Among them, intrauterine, intravenous and intraperitoneal injection deliver the best efficacy with low dosage and precise action.

It competitively antagonizes progesterone in the human body and inhibits the proliferation of placental trophoblast cells, thereby blocking pregnancy development. Its semi-synthetic derivatives show stable anti-early pregnancy effects, leading to placental villus atrophy, interstitial edema and trophoblast cell apoptosis. It is a vital natural leading compound for new contraceptive drug research.

6. Cholagogic & Liver Protection Effects

Andrographolide promotes bile secretion and metabolism, increases liver weight, shortens drug-induced sleep time and accelerates liver metabolism.

Pre-administration can strongly resist chemical liver damage caused by carbon tetrachloride, D-galactosamine and acetaminophen. It effectively reduces abnormal liver function indicators such as SGPT, SGOT, SALP and HTG, relieves hepatocellular inflammation and necrosis, and repairs damaged liver tissue. It is an ideal raw material for liver-nourishing and heat-clearing health products.

7. Tumor Proliferation Inhibition & Anti-Tumor Research Application

Dehydroandrographolide succinate exhibits obvious inhibitory activity on W256 transplanted tumors. Andrographolide arginine compound can suppress tumor cell growth at low, medium and high doses in a dose-dependent and stable manner.

In vitro cell experiments verify that andrographolide inhibits DNA synthesis of breast cancer cells and blocks cancer cell division. It is widely used in anti-tumor formula research, anti-cancer health products and biomedical laboratory studies.

8. Sedation & Endocrine Regulation

Andrographis-related preparations show mild and obvious sedative effects, which can shorten anesthesia induction time, prolong sedation period and enhance the efficacy of sedative drugs.

Andrographolide improves adrenal cortical function. High-dose andrographin A/B/C/D regulate thymus development in young animals, balance endocrine and gland immunity, and are widely used in endocrine conditioning and physical weakness recuperation formulas.

Product Safety, Toxicity Tolerance & Quality Assurance

Andrographolide features high clinical safety with extremely low side effects and good tolerance under conventional long-term usage.

The oral LD50 of Andrographis extract in mice is 13.19g/kg (calculated by andrographolide). It owns a sufficient safety range. Only high-concentration crude methanol extract carries slight liver accumulation risks. Our refined and purified products completely remove harmful impurities with zero residual toxicity, and every batch passes strict quality testing.

Application Industries & Supply Advantages

Our high-purity Andrographolide is widely used in dietary supplements, pharmaceutical compounds, anti-inflammatory oral liquids, external antibacterial products, pharmacological research and pet health raw materials.

We maintain sufficient stable inventory with bulk spot supply. Customized purity specifications, third-party test reports and complete export documents are available. Mass production ensures consistent batch quality with standardized dust-free workshop production and traceable production process. It is the preferred natural plant extract for global cross-border e-commerce, brand manufacturers and bulk procurement buyers.