Palmatine / Fibrauretine – High Purity Natural Medicinal Plant Extract Manufacturer

Fibrauretine, also known as Palmatine, is a high-activity alkaloid derived from natural plants. It is a widely applied natural antibacterial and anti-inflammatory plant extract in the pharmaceutical industry. Featuring stable efficacy and high safety, it has become a preferred raw material for pharmaceutical and health product manufacturers. As top trending search terms in Google, fibrauretine raw material, pure palmatine and natural antibacterial plant alkaloid are highly searched by global buyers.

Clinical Indications

With mature clinical application, Fibrauretine is widely used to treat various inflammations caused by bacterial infection.

For internal use, it effectively relieves upper respiratory tract infection, tonsillitis, enteritis, dysentery, urinary tract infection, as well as surgical and gynecological bacterial inflammatory diseases with excellent heat-clearing, detoxifying, antibacterial and anti-inflammatory effects.

For external use, it can be prepared into eye drops to treat conjunctivitis, and topical vaginal preparations to improve Candida albicans infection. It is a premium natural medicinal raw material for both internal and external application.

Core Pharmacological Effects

1. Effects on Nervous System

Palmatine delivers clear regulatory effects on the nervous system. Pharmacological experiments show that intraperitoneal injection of palmatine iodide at 20μg/kg and 50μg/kg can reduce spontaneous activity and conditioned reflexes in mice. At the dosage of 100μg/kg, it helps relieve muscle tension.

Besides, palmatine competitively blocks α-adrenergic receptors including α1 and α2 receptors. It reduces the specific binding capacity of cell membrane receptors, blocks nerve signal transmission, and possesses great development value for neuroregulatory medicine research.

2. Effects on Cardiovascular System

Cardiac Protection

Palmatine shows mild excitatory effects on isolated frog hearts. At the concentration of 50μmol/L, it reduces the automaticity and prolongs the functional refractory period of isolated guinea pig right ventricular papillary muscles, without affecting myocardial excitability and contractility.

Within the concentration of 10～100μmol/L, it prolongs the action potential duration in a dose-dependent manner, and decreases Vmax at 100μmol/L.

Berberine hydrochloride can reduce the myocardial infarction area caused by coronary artery ligation in rabbits. It has no calcium antagonism or β-receptor blocking effects, ensuring higher safety for cardiac related application.

Blood Pressure Regulation

Palmatine presents stable hypotensive activity. Intravenous injection at 10mg/kg leads to obvious blood pressure reduction in anesthetized rabbits and cats. Repeated administration enhances the efficacy without rapid tolerance. Long-term hypotensive effects can also be achieved via intraperitoneal injection or oral administration.

Its hypotensive mechanism is irrelevant to direct cardiovascular action. It works by blocking ganglia, inhibiting vasomotor center and antagonizing sympathetic mediators. Similar to berberine, it delivers mild and long-lasting effects, ideal for the research and development of hypertension conditioning supplements.

3. Antibacterial Activity

The antibacterial performance of palmatine is comparable to berberine with outstanding broad-spectrum bacteriostatic properties.

It strongly inhibits common pathogenic bacteria such as Staphylococcus aureus, dysentery bacillus, Escherichia coli and Streptococcus hemolyticus, including drug-resistant Staphylococcus aureus.

It also suppresses 12 kinds of molds, influenza A virus and acid-fast bacilli. The minimum inhibitory concentration against Candida albicans is as low as 250μg/ml, proving powerful antifungal capacity. It is a high-quality natural antibacterial plant raw material.

4. Anti-inflammatory Effects

Palmatine exerts anti-inflammatory activity by regulating the pituitary-adrenocortical system. It induces obvious thymus atrophy in young mice and reduces vitamin C content in rat adrenal glands with stable long-term efficacy after continuous administration.

It stimulates the release of histamine and 5-HT in the body to promote ACTH secretion and activate adrenocortical functions, so as to inhibit inflammatory reactions fundamentally and relieve inflammatory symptoms, with no side effects of synthetic anti-inflammatory drugs.

5. Other Pharmacological Functions

– Anti-cancer Activity: Strongly inhibits oxygen uptake of mouse ascites cancer cells, blocks cancer cell metabolism and proliferation, with great potential for anti-tumor research.

– Anti-trypanosome Effect: It kills most trypanosomes after 1-hour treatment at a dilution ratio of 1:4000.

– Smooth Muscle Regulation: Promotes spontaneous movement of isolated intestinal tracts; high concentration regulates intestinal tension and inhibits abnormal peristalsis. It excites uterine smooth muscle of rabbits and rats and displays high anticholinesterase activity to regulate gastrointestinal and uterine functions.

Application Fields

As a high-purity natural medicinal raw material, Fibrauretine is mainly used in pharmaceutical preparations, including oral tablets, eye drops and gynecological external products for various infectious and inflammatory diseases.

It is widely adopted in health supplement development for antibacterial, anti-inflammatory, blood pressure regulating and cardiovascular conditioning products.

Thanks to its natural bacteriostatic and anti-inflammatory properties, it is also widely used in daily chemicals and disinfection products, covering diversified application scenarios to meet customized production needs of global clients.

As a professional manufacturer of natural plant extracts, we strictly control raw material selection and full production processes. Every batch of products undergoes strict testing to guarantee high purity and low impurities.

We support customized specifications, small-batch trial orders and bulk wholesale. Providing stable, compliant and cost-effective Fibrauretine & Palmatine raw materials, we sincerely welcome global customers for inquiry and long-term strategic cooperation.