Tetrahydropalmatine | High‑Purity Natural Pharmaceutical Alkaloid Raw Material
– Chinese Name: Tetrahydropalmatine; Aliases: Tetrahydropalmatine, Rotundine
– English Name: Tetrahydropalmatine (THP)
– CAS No.: 6024‑85‑7 (Hydrochloride)
– Natural Source: The core analgesic active ingredient extracted from Corydalis Rhizoma, a medicinal herb of the Papaveraceae family
– Appearance: White to off‑white crystalline powder
Derived from Corydalis Rhizoma, a well‑known traditional medicinal herb, Tetrahydropalmatine (also named Rotundine) is a premium active alkaloid widely recognized in global pharmaceutical, nutraceutical and scientific research fields. Featuring natural mild activity, low dependence risk and multi‑target pharmacological effects, it has become a preferred raw material for international pharmaceutical manufacturers, bulk buyers and research institutes.
Our supplied product is DL‑Tetrahydropalmatine Hydrochloride, appearing as white to off‑white crystalline powder with CAS No. 6024‑85‑7. Produced under standardized extraction and purification processes, it maintains stable purity and consistent batch quality, meeting bulk purchase requirements for pharmaceutical synthesis, formulation development, reference standards and dietary supplement raw materials, fully compliant with regulations for European, American and Southeast Asian markets.
Basic Physicochemical Properties
– Free Tetrahydropalmatine: Molecular formula \mathrm{C_{21}H_{25}NO_4} , molecular weight 355.42
– Tetrahydropalmatine Hydrochloride (main commercial form): Molecular formula \mathrm{C_{21}H_{26}ClNO_4} , molecular weight 391.89
Three chiral forms are available:
– Levo‑isomer (main pharmacologically active): Melting point 147 ℃ for free form; 210 ℃ for hydrochloride
– Dextro‑isomer: Melting point 141–142 ℃
– Racemic form (DL‑THP): Melting point 148–149 ℃ for free form; 215–216 ℃ for hydrochloride
We provide bulk raw materials and 20 mg reference standards, support customized packaging and large‑volume supply with steady stock and fast delivery.
Core Pharmacological Benefits (Key Selling Points for Overseas Buyers)
- Non‑addictive Natural Analgesic & Sedative
Unlike addictive opioid analgesics, Tetrahydropalmatine acts on central dopamine receptors to increase enkephalin levels in the brain. It delivers gentle yet effective relief for chronic dull pain including neuralgia, vascular headache, stomachache and dysmenorrhea. At regular dosages, it causes no addiction or respiratory suppression. Its mild sedative effect also improves pain‑related insomnia and anxiety, ideal for pain‑relief pharmaceuticals and natural health supplements.
- Cardiovascular & Neuroprotective Effects
It inhibits abnormal calcium influx and neuronal apoptosis to reduce cerebral ischemia‑reperfusion injury and protect vascular endothelium. Meanwhile, it suppresses platelet aggregation and thrombosis, delivers sustained blood pressure reduction and anti‑arrhythmic effects for supraventricular tachycardia and atrial fibrillation, with safe and long‑lasting performance.
- Gastroprotective & Anti‑ulcer Activity
It non‑competitively inhibits gastric acid secretion, relieves hyperacidity and stubborn stomach pain, and alleviates stress‑induced and pylorus‑ligated gastric ulcers, making it a reliable raw material for gastrointestinal formulations.
- Unique Research & Clinical Value
It effectively relieves withdrawal symptoms caused by opioids and amphetamines, supporting addiction rehabilitation research. At high concentrations, it shows in‑vitro anti‑tumor activity. It is also clinically applied in relieving intractable hiccups, severe cough and pediatric diarrhea, offering broad potential for formulation development and academic research.
Global Applications & Our Advantages
Our products are exported to pharmaceutical factories, biotech enterprises and research labs worldwide for:
– Prescription drugs for analgesia, sedation, hypertension and arrhythmia treatment
– Natural dietary supplements for pain relief and nerve support
– Reference standards for laboratory testing and pharmaceutical intermediates
– Herbal formulations for integrative medicine
We strictly control purity, heavy metal and microbial indicators with complete COA certificates and full export documentation. Flexible trade terms including FOB and CIF are available. Customized purity and packaging services ensure stable, cost‑effective and one‑stop raw material supply for global partners.
Safety & Precautions
Well‑tolerated at standard doses. Occasional mild side effects include dizziness, fatigue, nausea and drowsiness. High doses may slightly suppress respiration and rarely cause extrapyramidal symptoms. Not recommended for pregnant women. Due to sedative properties, avoid driving or operating machinery after use.
Product Inquire Now
"*" indicates required fields
